The Browns were already in for a tough challenge this week, heading to Tampa Bay to meet an extremely motivated old friend in his home opener.
That challenge got even tougher when CB Tyson Campbell hit the injury report on Thursday. Campbell wasn’t on the injury report to begin this week, but he missed Thursday’s practice with an ankle injury.
Campbell returned to practice on Friday and will carry a “questionable” injury designation into Sunday’s game. Browns coach Todd Monken said the team wants to see how Campbell responds to Friday’s practice before making a decision.
The Browns are sizable underdogs on Sunday in Tampa. Baker Mayfield will get his first crack against Deshaun Watson since the infamous 2022 saga that saw the Browns move on from the former first overall pick.
Many are projecting Baker and the Bucs will have their way with the Browns down in Florida on Sunday afternoon. Earlier this week, we highlighted the narratives and outlined how that match up might shake out.
However, with the Campbell injury news and more time having passed, DraftKings has updated their odds once again ahead of Sunday’s Week 2 affair.
Browns vs. Buccaneers: DraftKings odds for NFL Week 2
For Sunday’s Week 2 clash between the Browns and Buccaneers, DraftKings provides a wide range of betting markets—ranging from side and total wagers to specific team scoring and player touchdown props.
Game lines
MarketBrownsBuccaneersMoneyline+350-455Spread+8.5 (-112)-8.5 (-108)TotalOver 41.5 (-110)Under 41.5 (-110)
The DraftKings odds point to a lopsided Week 2 matchup, with Tampa Bay expected to win their home-opener as their starting quarterback looks for revenge on the team that gave up on him.
DraftKings odds change and update in real time.
NFL prediction markets:
Local Browns and Buccaneers fans in Ohio and Florida can use prediction markets to trade on NFL football outcomes as an alternative to traditional sports betting. Here are our top options, along with the available promo codes for eligible new users:
PlatformNFL Eligible?Sept. ’26 Sign-Up BonusVerified Promo CodesPolymarketYes$50CUSE, MASS, OREGON, SILIVE, CLEVEKalshiYes$25SYRACUSE, OREGONLIVE1, MASSLIVE1, SILIVE, CLEVELANDUnderdogYes$50CUSE, MASS, OREGON
New users registering with the Kalshi promo code CLEVELAND deposit $25 and receive a $25 bonus, creating $50 in total trading funds before taking a position.
NFL betting preview: Cleveland Browns vs. Tampa Bay Buccaneers
Use the interactive widget below to track the latest spread, total, moneyline odds and implied probabilities for Sunday’s Browns-Bucs matchup in Tampa.
Here are the key details for Sunday’s matchup, including the latest traditional odds:
Game details
- Teams: Cleveland Browns vs. Tampa Bay Buccaneers
- Date: Sunday, September 20, 2026
- Time: 1:00 PM ET
- Venue: Raymond James Stadium| Tampa, FL
- TV: CBS, Paramount+
- NFL info: Stats, rosters and injury reports
- NFL standings: Current NFL regular season standings
- NFL news: Check the latest updates from the official NFL news site
Expert Prediction: Browns vs. Buccaneers
The experts at Dimers have run over 10,000 simulations of Sunday’s matchup between the Browns and the Buccaneers. The model assigns the Bucs a 75.7% win probability compared with 24.3% for the Browns and lands on a Buccaneers 25, Browns 16 projected final score. That projected margin fits with the 8.5-point spread currently available at DraftKings.
Best Bet: Buccaneers Team Total over 24.5
Taking Tampa Bay over 24.5 points is our top pick. For starters, Cleveland’s defense got shredded by Trevor Lawrence and the Jaguars in Week 1, surrendering 34 points in under three quarters before Jacksonville simply eased off the gas. Meanwhile, the Bucs dropped 27 points on a upgraded Bengals defense despite turning the ball over four times. Tampa didn’t punt once; cut out those giveaways and they likely win the game and score near 40. Throw in the revenge factor of Baker Mayfield itching to drop a hundred on his former team against a Browns defense that looks powerless to stop it, and the over on Tampa’s team total feels like the way to go.
Player props: Anytime Touchdown probabilities
PlayerTeamAnytime TD oddsBucky IrvingBuccaneers-130Quinshon JudkinsBrowns+140Emeka EgbukaBuccaneers+145Kenneth GainwellBuccaneers+200Chris GodwinBuccaneers+200Sean TuckerBuccaneers+255Cade OttonBuccaneers+260
These Browns vs. Buccaneers predictions, based on sophisticated simulations and current data, can guide you in making informed decisions. Remember to bet responsibly and within your financial limits.
For further insights, explore Dimers’ expert NFL predictions and the best NFL bets today, while their in-depth analysis includes NFL picks, NFL props, NFL futures, NFL odds, and the latest NFL news.
Conclusion: DraftKings favors Bucs over Browns in NFL Week 2
The Baker Mayfield-Browns breakup has favored Baker almost every step of the way, and oddsmakers are expecting that to continue on Sunday afternoon. A lopsided game is expected, but DraftKings gives bettors multiple ways to approach the opener beyond the outright winner, including spreads, totals, team scoring and touchdown markets.
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