The Cleveland Cavaliers begin their season on Thursday, October 22, 2026, when the team travels to Xfinity Mobile Arena to take on LeBron James and the Philadelphia 76ers. Tip off is scheduled for 7:00 p.m. EST and will air on ESPN.
Each new season brings new expectations, and the Cavaliers have plenty with some added talent to the roster headlined by Peyton Watson joining the team in free agency this past summer.
Following the latest injury updates, Sam Merrill (elbow) is the biggest name on the Cavaliers’ report. He will be a game time decision for Thursday after not participating in the team’s scrimmage on Saturday. Nae’Qwan Tomlin (back) and Khalifa Diop (knee) are also hurt.
Meanwhile, the 76ers have plenty of injuries of their own. Dean Wade (ankle), Adem Bona (foot), Anfernee Simons (hamstring), Tacko Fall (hip), and Dominick Barlow (spine) are all on the current injury report.
As a result, the data analysts at Dimers released their Cavaliers-76ers score prediction after conducting new simulations that took into account every element of matchup data.
The results of Dimers’ simulations were compared to updated sportsbook odds to compile the data-driven Cavs vs. 76ers preview below.
Cleveland vs. Philadelphia betting preview
Explore the interactive widget below to discover the current spread, over/under, and moneyline betting odds and probabilities for the Cavaliers-76ers matchup at Xfinity Mobile Arena.
This prediction and best bet for Thursday’s NBA matchup between the Cavs and 76ers is from Dimers.com, a dependable source for sports betting predictions.
Check out all the important details on tonight’s game, as well as the best odds sourced from the top prediction markets in the country.
Game details
Key information on this Cavaliers-76ers matchup, including where the game is and what time it kicks off.
- Teams: Cleveland Cavaliers vs. Philadelphia 76ers
- Date: Thursday, October 22, 2026
- Time: 7:00 p.m. EST
- Location: Xfinity Mobile Arena (Philadelphia, Penn.)
- NBA injuries: Check the latest updates to the official NBA injury report
NBA Thursday Odds
Kalshi is one of the best platforms to trade on ahead of kickoff. Here is the currently outlook of key markets for the Cavs-76ers NBA Game.
- Spread: Cavaliers +2.5 (53¢), 76ers -2.5 (52¢)
- Moneyline: Cavaliers: 46¢, 76ers: 56¢
- Total: Over/Under 235.5 (53¢/53¢)
Win probability
TeamExpert %Cleveland Cavaliers40.2%Philadelphia 76ers59.8%
Expert prediction: Cavs vs. 76ers
Using trusted data analysis and machine learning, the experts at Dimers have performed 10,000 simulations of Thursday’s Cavaliers vs. 76ers matchup.
According to Dimers’ popular predictive analytics model, the 76ers are more likely to beat the Cavaliers at Xfinity Mobile Arena. This prediction is based on the model giving the Cavs an 40.2% chance of winning the game.
Furthermore, Dimers predicts that the Cavaliers at +2.5 have a 49.6% chance of covering the spread. The over/under total of 235.5 points leans 53.6% toward the under.
As always, these predictions and probabilities are accurate at the time of publication but are subject to change.
Cavaliers vs. 76ers best bet
Our top pick for Thursday’s game is to bet on Under 235.5 (53¢). With around a 53.6% probability, it offers a promising edge to capitalize on ahead of the showdown.
This betting advice is formulated through world-class modeling and valuable betting intelligence, designed to help you make more informed investments.
Win prediction for Cavaliers vs. 76ers
Dimers’ predicted final score for the Philadelphia vs. Cleveland game on Thursday has the 76ers winning 119-116.
This expert prediction is based on each team’s average outcome following 10,000 game simulations, offering a glimpse into the potential outcome.
NBA player props: Saturday
NBA player prop bets offer a popular way to place wagers on the Cavaliers vs. 76ers matchup without having to bet on the outcome of the game itself.
Dimers, armed with the most reliable information available, projects how each team’s leading players will perform at Xfinity Mobile Arena.
Donovan Mitchell headlines the Cavaliers’s projection tonight with an expected 28 points, 5 rebounds, and 5 assists. For the 76ers, Jaylen Brown is projected to finish with 24 points, 6 rebounds, and 5 assists.
Projected Box Score for Cavs-76ers
Cleveland Cavaliers
PlayerPTSREBASTD. Mitchell2855J. Harden2257E. Mobley1894P. Watson1652J. Allen1482
Philadelphia 76ers
PlayerPTSREBASTJ. Brown2465J. Embiid2384T. Maxey2135L. James1768V. Edgecombe1353
NBA Thursday: 76ers vs. Cavs
Get ready for Thursday’s Eastern Conference showdown when the Cleveland Cavaliers travel to take on the Philadelphia 76ers for the NBA season opener scheduled for 7:00 PM EST at Xfinity Mobile Arena.
The Cavaliers travel to take on franchise legend LeBron James in his home opener for the 76ers. Additionally, this is the first look at Cleveland for the regular season.
Last season, the Cavs played the 76ers four times and swept the regular season series. The teams are very different this year, but they’ll look to keep that momentum going on Thursday night.
NBA picks and prediction market props add an enjoyable dimension to the biggest weekend on the American sports calendar.
All NBA predictions in this article are derived from 10,000 data-driven simulations of the 76ers vs. Cavaliers matchup and are accurate at the time of publishing. It is important to gamble responsibly and seek trustworthy sources for the latest and most accurate information when making online betting choices.
NBA Prediction market sign-up bonuses
Cavs and 76ers fans across the US can use prediction markets to trade on the NBA opener as an alternative to standard betting. Here are the top options and available promo codes for new users:
PlatformNBA/MLB Eligible?September ’26 Sign-Up BonusVerified Promo CodesPolymarketYes$50CUSE, MASS, OREGON, SILIVE, CLEVEKalshiYes$25SYRACUSE, OREGONLIVE1, MASSLIVE1, SILIVE, CLEVELANDNovigYes$50SYRACUSE, OREGON, MASSLIVE, CLEVELAND
Kalshi is a prediction market platform, not a sportsbook. Users trade positions on event outcomes using real funds. Must be 18+ and eligible under applicable law. Trading involves risk. Prices reflect the market at time of writing and are subject to change. All times listed are EDT.
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