Xojiakbar Alijonov scored the sole goal of the match in the 120th minute at the Olympic City Stadium in Tashkent. Eldor Shomurodov had missed a penalty in the 105th minute, according to a report by Tehran Times newspaper.
Iran’s Arya Yousefi was shown a red card just five minutes into the match.
Earlier in the day, India defeated Oman 3-2 in a penalty shootout after the match ended 1-1 in regular time.
Iran began the campaign in Group B with a 3-1 win over Afghanistan and then defeated India 3-0. Team Melli were held to a 2-2 draw against Tajikistan but topped the group, earning a berth in the final.
Iran had won the inaugural CAFA Nations Cup two years ago, edging past Uzbekistan 1-0 in the final.
MNA