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Iran has launched a retaliatory missile attack on Israel, with Iranian projectiles striking seven locations across the country, Israeli military sources said on Friday.

Israel’s Army Radio reported that emergency teams are operating at the impacted sites and that work is continuing in the affected areas.

The Magen David Adom emergency service confirmed that seven people have been injured in the attacks so far.

The Israeli military said dozens of missiles had been launched from Iran and that air defence systems were working to intercept them.

Due to the missile launches, alarms continued to sound across various parts of Israel throughout the incident, signalling a heightened state of alert nationwide.

“We will not allow them to escape safely from this great crime they committed,” Iran’s Supreme Leader Ayatollah Ali Khamenei said in a recorded message in which he vowed revenge.

An Associated Press reporter saw smoke rising in Tel Aviv after an apparent missile strike. A Tel Aviv area hospital said it was treating 15 injured civilians.

US ground-based air defense systems in the region are helping to shoot down Iranian missiles, said a US official who spoke on condition of anonymity to discuss the measures.

On Thursday, Iran had been censured by the UN’s atomic watchdog for not complying with obligations meant to prevent it from developing a nuclear weapon.

Countries in the region condemned Israel’s attack, while leaders around the globe called for immediate deescalation from both sides.

The UN Security Council scheduled an emergency meeting for Friday afternoon at Iran’s request. In a letter to the council, Iran’s Foreign Minister Abbas Araghchi called the killing of its officials and scientists “state terrorism” and affirmed his country’s right to self-defense.

Israel’s military said about 200 aircraft were involved in the initial attack on about 100 targets. Its Mossad spy agency positioned explosive drones and precision weapons inside Iran ahead of time, and used them to target Iranian air defenses and missile launchers near Tehran, according to two security officials who spoke on condition of anonymity.

It was not possible to independently confirm the officials’ claims.

Among the key sites Israel attacked was Iran’s main nuclear enrichment facility in Natanz, where black smoke could be seen rising into the air. It also appeared to strike a second, smaller nuclear enrichment facility in Fordo, about 100 kilometers (60 miles) southest of Tehran, according to an Iranian news outlet close to the government that reported hearing explosions nearby.

Israel said it struck a nuclear research facility in Isfahan, too, and said it destroyed dozens of radar installations and surface-to-air missile launchers in western Iran. Iran confirmed the strike at Isfahan.

Israel military spokesman Brig. Gen. Effie Defrin said the Natanz facility was “significantly damaged” and that the operation was “still in the beginning.”

The first wave of strikes had given Israel “significant freedom of movement” in Iran’s skies, clearing the way for further attacks, according to an Israeli military official who spoke on condition of anonymity because he was not authorized to discuss details of the attack with the media.

The official said Israel is prepared for an operation that could last up to two weeks, but that there was no firm timeline.

Among those killed were three of Iran’s top military leaders: one who oversaw the entire armed forces, Gen. Mohammad Bagheri; one who led the paramilitary Revolutionary Guard, Gen. Hossein Salami; and the head of the Guard’s ballistic missile program, Gen. Amir Ali Hajizadeh.

Iran confirmed all three deaths, significant blows its governing theocracy that will complicate efforts to retaliate. Khamenei said other top military officials and scientists were also killed.

Netanyahu said the attack had been months in the making. In a video statement sent to journalists Friday, he said he ordered plans for the attack last November, soon after the killing of Hassan Nasrallah, the leader of Hezbollah in Lebanon, one of Iran’s strongest proxies. Netanyahu said the attack was planned for April but was postponed.

In its first response Friday, Iran fired more than 100 drones at Israel. Israel said the drones were being intercepted outside its airspace, and it was not immediately clear whether any got through.

Israel’s military said it called up reservists and began stationing troops throughout the country as it braced for further retaliation from Iran or Iranian proxy groups.

Trump urged Iran on Friday to reach a deal with the US on its nuclear program, warning on his Truth Social platform that Israel’s attacks “will only get worse.”

“Iran must make a deal, before there is nothing left, and save what was once known as the Iranian Empire,” he wrote.

Federman and Frankel reported from Jerusalem. Associated Press writers Nasser Karimi, Amir Vahdat and Mehdi Fattahi in Tehran, Iran; Melanie Lidman and Sam Mednick in Tel Aviv, Israel; Lolita C. Baldor, Tara Copp, Matthew Lee and Eric Tucker in Washington; Bassem Mroue and Abby Sewell in Beirut; Edith Lederer at the United Nations and David Rising in Bangkok contributed to this report.